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The blood-to-plasma ratio for eszopiclone is less than one, eszopiclone indicating no selective uptake by red blood cells .
Following oral administration, eszopiclone is extensively lunesta problems 6 mg lunesta high can lunesta keep you awake lunesta vs ambien night lunesta in metabolized by oxidation and demethylation .
The primary plasma metabolites are (S)-zopiclone-N-oxide and lunesta vs valium lunesta 2 mg high lunesta side effects hair loss lunesta side effects long term (S)-N-desmethyl zopiclone; the latter compound binds to GABA receptors with substantially lower potency than eszopiclone, and the former compound shows no significant binding to this receptor .
In vitro studies have shown that eszopiclone CYP3A4 and CYP2E1 enzymes are involved in the metabolism of eszopiclone .
Eszopiclone did not show any inhibitory potential on CYP450 1A2, 2A6, 2C9, 2C19, 2D6, 2E1, eszopiclone bitter taste lunesta reviews for insomnia lunesta dea schedule lunesta used for anxiety and 3A4 in cryopreserved human hepatocytes .
After eszopiclone oral administration, eszopiclone is eliminated with a mean t1/2 of approximately 6 hours .
Up to 75% of an oral dose of racemic zopiclone is excreted in the urine, primarily as eszopiclone metabolites .
A similar excretion profile lunesta double dosage side effects with lunesta lunesta category lunesta samples lunesta would be expected for eszopiclone, the S-isomer of racemic zopiclone .
Less than 10% of eszopiclone the orally administered eszopiclone dose is excreted in the urine as In healthy adults, administration of a 3 mg dose of eszopiclone after a high-fat meal resulted in no change in AUC, a reduction in mean Cmax of 21%, and delayed tmax by approximately 1 hour .
The half-life remained unchanged, eszopiclone approximately 6 hours .

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